Therapeutic Drug Delivery
Therapeutic drug delivery, including immunotherapy and cancer vaccines, aim to improve clinical outcomes.
Unfortunately, cancer remains one of the leading causes of death worldwide. In 2022, WHO estimated 20 million new cancer cases are identified annually causing around 9.7 million of deaths. Of these, 2.3 million are caused by infectious diseases. In particular, Hepatitis B (HBV) and Human Papilloma Virus (HPV) are responsible for 48% of these.
Did you know vaccines can prevent cancer?
Currently, two preventive cancer vaccines are available. HPV vaccines are highly effective in preventing infections from high-risk HPV types causing over 70% of cervical cancers, while HBV vaccines are in preventing Hepatis B infections causing chronic liver disease and liver cancer.
Check out our ‘Did you know series’: Did you know vaccines can prevent cancer
Also, read more in our HepB white paper and our HPV white paper.
Therapeutic cancer vaccines
Bacillus Calmette-Guérin (BCG) vaccine is commonly linked to prevention of Tuberculosis, but is also used to treat bladder cancer. Also, a dendritic cell-based vaccine (Sipuleucel-T) is commercially available for castration-resistant prostate cancer.
Additionally, several therapeutic cancer vaccines are in development or in the preclinical or clinical research phase.
Check out our ‘Did you you know series’ on melanoma and our blog on prostate cancer.
Auto-immune diseases
Importantly, immunotherapy supports not only cancer treatment, like breast and prostate cancer but also auto-immune diseases, like multiple sclerosis and rheumatoid arthritis.
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VAX-ID for reliable therapeutic drug delivery
VAX-ID is a CE marked device that offers a promising dose-sparing solution improving availability and affordability of cancer vaccines. Furthermore, VAX-ID offers a promising solution for reliable delivery of cell-based immunotherapy. In particular, VAX-ID allows for intradermal administration of tolerogenic dendritic cells to treat auto-immune diseases such as multiple sclerosis (MS).
Importantly, for the treatment to be effective, it is important that viable and functional cells are not damaged by shear stress and reach the site of action without change in cell phenotype. Also, viscosity of the cells often causes counterpressure while injecting. VAX-ID easily resolves these challenges.
Curious to find out more about VAX-ID? Check out the VAX-ID product page here.