Prophylactic vaccinations are saving lives
The discovery and development of prophylactic or preventive vaccines remains one of the major successes of global health saving millions of lives every year. (PMID: 34197271)
Today, more than 20 life-threatening diseases can be prevented by prophylactic vaccination, helping people of all ages live longer and healthier lives.
Furthermore, the widespread use of COVID-19 mRNA vaccines accelerates mRNA vaccine technology leading to the development of future prophylactic as well as cancer vaccines.
Read more on therapeutic drug delivery
Pandemics and Health Emergencies
Future pandemics are inevitable, but it is unlikely, that vaccine production plants can be scaled up rapidly enough to immunize the critical proportion of 60–70% of the world’s population. Therefore, dose-sparing approaches such as intradermal vaccination can offer a solution.
Dose-sparing effect of a fractional prophylactic vaccination dose
Numerous studies show that for vaccines like Hepatitis B, influenza, rabies, Polio, Yellow Fever and SARS-CoV-2 and others, intradermal (ID) prophylactic vaccination using a fractional dose of 1/5th or even 1/10th of the full dose exhibits a similar or non-inferior immune response compared to intramuscular (IM) or subcutaneous (SC) vaccination. (PMID: 32898704; White paper on prophylactic vaccination)
